LetterRecurrent life-threatening acidosis induced by acetazolamide in a patient with diabetic type iv renal tubular acidosis
Section snippets
To the Editor:
Carbonic anhydrase inhibitors are widely used for the treatment of wide-angle glaucoma and are usually well tolerated. Severe metabolic acidosis, rarely reported, occurs predominantly among elderly people, in patients with advanced renal failure, in patients on chronic dialysis, and during concomitant use of other nephrotoxic drugs.1, 2, 3, 4, 5
An 80-year-old male patient was admitted with progressive tachypnea and declining mental status. Past medical history included non–insulin-dependent
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Carbonic anhydrase inhibitor side effects
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Significant metabolic acidosis induced by acetazolamide. Not a rare complication
Arch Intern Med
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2023, Pharmacology and TherapeuticsSevere Metabolic Acidosis and Hyperammonemia Induced by the Concomitant Use of Acetazolamide and Aspirin in a Patient With Impaired Renal Function
2021, Journal of Emergency MedicineCitation Excerpt :Severe hyperchloremic acidosis associated with acetazolamide use is rare. The publication of case reports has led to increased concern regarding patients with advanced renal function impairment (6,7). Acetazolamide is contraindicated only in patients undergoing dialysis and can be used in patients with impaired renal function if the dosage is adjusted.
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