Quantitative spatiotemporal image analysis of fluorescein angiography in age-related macular degeneration

Jeffrey W. Berger M.D.

doi:10.1117/12.309435

1 June 1998 Quantitative spatiotemporal image analysis of fluorescein angiography in age-related macular degeneration

Jeffrey W. Berger M.D.

Proceedings Volume 3246, Ophthalmic Technologies VIII; (1998) https://doi.org/10.1117/12.309435
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Interpretation and analysis of retinal angiographic studies has been largely qualitative. Quantitative analysis of pathologic fundus features will facilitate interpretation and potentiate clinical studies where precise image metrology is vital. Fluorescein angiography studies of patients with age- related macular degeneration were digitized. Sequential temporal images were spatially-registered with polynomial warping algorithms, allowing for the construction of a three- dimensional (two spatial and one temporal) angiogram vector. Temporal profiles through spatially-registered, temporally- sequential pixels were computed. Characteristic temporal profiles for fundus background, retinal vasculature, retinal pigment epithelial atrophy, and choroidal neovascular (CNV) membranes were observed, allowing for pixel assignment and fundus feature quantitation. Segmentation and quantitation of fundus features including geographic atrophy and CNV is facilitated by spatio-temporal image analysis.

Citation Download Citation

Jeffrey W. Berger M.D. "Quantitative spatiotemporal image analysis of fluorescein angiography in age-related macular degeneration", Proc. SPIE 3246, Ophthalmic Technologies VIII, (1 June 1998); https://doi.org/10.1117/12.309435

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