Molecular mechanisms of copper homeostasis

Biochem Biophys Res Commun. 1999 Aug 2;261(2):225-32. doi: 10.1006/bbrc.1999.1073.

Abstract

Copper is an essential trace element which plays a pivotal role in cell physiology as it constitutes a core part of important cuproenzymes. Novel components of copper homeostasis in humans have been identified recently which have been characterised at the molecular level. These include copper-transporting P-type ATPases, Menkes and Wilson proteins, and copper chaperones. These findings have paved the way towards better understanding of the role of copper deficiency or copper toxicity in physiological and pathological conditions.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / chemistry
  • Adenosine Triphosphatases / genetics
  • Adenosine Triphosphatases / metabolism
  • Amino Acid Sequence
  • Animals
  • Carrier Proteins / chemistry
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Cation Transport Proteins*
  • Copper / deficiency
  • Copper / metabolism*
  • Copper / toxicity
  • Copper-Transporting ATPases
  • Hepatolenticular Degeneration / metabolism
  • Homeostasis
  • Humans
  • Menkes Kinky Hair Syndrome / genetics
  • Menkes Kinky Hair Syndrome / metabolism
  • Models, Biological
  • Molecular Chaperones / metabolism
  • Recombinant Fusion Proteins*

Substances

  • Carrier Proteins
  • Cation Transport Proteins
  • Molecular Chaperones
  • Recombinant Fusion Proteins
  • Copper
  • Adenosine Triphosphatases
  • ATP7A protein, human
  • Copper-Transporting ATPases