Abstract
In 4 corneal transplantation patients treated preoperatively with ciprofloxacin ophthalmic drops, microprecipitates associated with damaged corneal epithelium were noted in 2 patients. Another patient developed a large macroprecipitate in a corneal ulcer. All specimens were examined by electron microscopy and high-pressure liquid chromatography. The crystalline precipitates were pure ciprofloxacin. The macroprecipitate demonstrated a large zone of inhibition on agar plates seeded with a susceptible organism at 24 and 48 hours. It was bioactive and bioavailable in vitro.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Aged
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Anti-Infective Agents / adverse effects*
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Antibiotic Prophylaxis*
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Chemical Precipitation
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Chromatography, High Pressure Liquid
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Ciprofloxacin / adverse effects*
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Corneal Transplantation
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Corneal Ulcer / chemically induced*
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Corneal Ulcer / pathology
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Epithelium, Corneal / drug effects*
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Epithelium, Corneal / ultrastructure
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Female
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Humans
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Microscopy, Electron, Scanning
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Ophthalmic Solutions
Substances
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Anti-Infective Agents
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Ophthalmic Solutions
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Ciprofloxacin