Fifty cases of amblyopia, including some cases of eccentric fixation, which had previously been successfully treated by various therapies (conventional occlusion, red filter occlusion and pleoptics) were followed up from 12 to 68 months. Fifteen cases (30%) deteriorated to pretreatment level during the follow up. Deterioration was found to be greater in cases over the age of 15 years and in cases who did not follow the instructions given to them after cessation of therapy.