Relating retinal nerve fiber thickness to behavioral sensitivity in patients with glaucoma: application of a linear model

J Opt Soc Am A Opt Image Sci Vis. 2007 May;24(5):1426-30. doi: 10.1364/josaa.24.001426.

Abstract

Glaucoma causes damage to the retinal ganglion cells and their axons, and this damage can be detected with both structural and functional tests. The purpose of this study was to better understand the relationship between a structural measure of retinal nerve fiber layer (RNFL) and the most common functional test, behavioral sensitivity with static automated perimetry (SAP). First, a linear model, previously shown to describe the relationship between local visual evoked potentials and SAP sensitivity, was modified to predict the change in RNFL as measured by optical coherence tomography. Second, previous work by others was shown to be consistent with this model.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Computer Simulation
  • Evoked Potentials, Visual
  • Glaucoma / pathology*
  • Glaucoma / physiopathology*
  • Humans
  • Linear Models
  • Models, Biological*
  • Nerve Fibers / pathology*
  • Nerve Fibers / physiology
  • Photic Stimulation / methods
  • Retinal Ganglion Cells / pathology*
  • Retinal Ganglion Cells / physiology
  • Statistics as Topic
  • Tomography, Optical Coherence / methods*