Therapeutic efficacy of intravitreal bevacizumab on posterior uveitis complicated by neovascularization

Acta Ophthalmol. 2009 May;87(3):349-52. doi: 10.1111/j.1755-3768.2008.01208.x. Epub 2008 Jun 28.

Abstract

Purpose: To evaluate the therapeutic effect of intravitreal bevacizumab in patients with uveitis-associated choroidal/retinal neovascularization.

Methods: Two female patients (40 years, 15 years) with posterior uveitis, (one presumed ocular sarcoidosis, one lupus) were evaluated for neovascularization of the posterior segment. Both patients were given a single dose of 1.25 mg intravitreal bevacizumab.

Results: Significant anatomical and functional recovery was evident in both patients within a few weeks.

Conclusion: In selected uveitic patients, bevacizumab may be an option for managing neovascularization.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Angiogenesis Inhibitors / administration & dosage*
  • Antibodies, Monoclonal / administration & dosage*
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab
  • Female
  • Humans
  • Injections
  • Middle Aged
  • Neovascularization, Pathologic / drug therapy*
  • Neovascularization, Pathologic / etiology*
  • Neovascularization, Pathologic / pathology
  • Treatment Outcome
  • Uvea / blood supply*
  • Uveitis / complications*
  • Vitreous Body

Substances

  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab