Tubulointerstitial nephritis and uveitis (TINU) syndrome caused by the Chinese herb "Goreisan"

Hisa Suzuki; Katsunobu Yoshioka; Masato Miyano; Isseki Maeda; Keiko Yamagami; Takashi Morikawa; Noriyuki Okada; Yoshio Konishi; Masahito Imanishi

doi:10.1007/s10157-008-0069-y

Tubulointerstitial nephritis and uveitis (TINU) syndrome caused by the Chinese herb "Goreisan"

Clin Exp Nephrol. 2009 Feb;13(1):73-6. doi: 10.1007/s10157-008-0069-y. Epub 2008 Jul 26.

Authors

Hisa Suzuki¹, Katsunobu Yoshioka, Masato Miyano, Isseki Maeda, Keiko Yamagami, Takashi Morikawa, Noriyuki Okada, Yoshio Konishi, Masahito Imanishi

Affiliation

¹ Department of Internal Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-Hondori, Miyakojima, Osaka, Japan. hisa406coupe@yahoo.co.jp

PMID: 18661195
DOI: 10.1007/s10157-008-0069-y

Abstract

A 58-year-old man was admitted to our hospital complaining of fever and arthralgia. His clinical course and marked ciliary hyperemia led us to suspect tubulointestinal nephritis and uveitis (TINU) syndrome, which was confirmed ophthalmologically and by renal biopsy. Results of a drug-induced lymphocyte-stimulating test were positive for the Chinese herb "Goreisan." This is the first case in which the use of "Goreisan" was causally related to TINU syndrome.

Publication types

Case Reports

MeSH terms

Anti-Inflammatory Agents / therapeutic use
Arthralgia / chemically induced
Biopsy
Drugs, Chinese Herbal / adverse effects*
Fever / chemically induced
Fluorescein Angiography
Humans
Kidney Glomerulus / drug effects*
Kidney Glomerulus / pathology
Male
Medicine, Kampo
Middle Aged
Nephritis, Interstitial / chemically induced*
Nephritis, Interstitial / drug therapy
Nephritis, Interstitial / pathology
Syndrome
Uveitis / chemically induced*
Uveitis / drug therapy
Uveitis / pathology
beta 2-Microglobulin / urine

Substances

Anti-Inflammatory Agents
Drugs, Chinese Herbal
beta 2-Microglobulin
gorei-san