Increased levels of 8-hydroxydeoxyguanosine in the vitreous of patients with diabetic retinopathy

Yoshihiro Wakabayashi; Yoshihiko Usui; Yusuke Shibauchi; Hiroyuki Uchino; Hiroshi Goto

doi:10.1016/j.diabres.2010.05.032

Increased levels of 8-hydroxydeoxyguanosine in the vitreous of patients with diabetic retinopathy

Diabetes Res Clin Pract. 2010 Sep;89(3):e59-61. doi: 10.1016/j.diabres.2010.05.032. Epub 2010 Jun 29.

Authors

Yoshihiro Wakabayashi¹, Yoshihiko Usui, Yusuke Shibauchi, Hiroyuki Uchino, Hiroshi Goto

Affiliation

¹ Department of Ophthalmology, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. wbaki@tokyo-med.ac.jp

PMID: 20591522
DOI: 10.1016/j.diabres.2010.05.032

Abstract

We determined the intravitreous level of 8-hydroxydeoxyguanosine (8-OHdG) in diabetic retinopathy (DR) and analyzed the relation between oxidative stress and DR. Vitreous 8-OHdG concentration increased significantly in 18 patients (20 eyes) with DR compared with controls with macular disease. This result suggests that increased oxidative stress is involved in DR.

MeSH terms

8-Hydroxy-2'-Deoxyguanosine
Aged
Deoxyguanosine / analogs & derivatives*
Deoxyguanosine / metabolism
Diabetic Retinopathy / drug therapy
Diabetic Retinopathy / metabolism*
Diabetic Retinopathy / pathology
Female
Humans
In Vitro Techniques
Male
Middle Aged
Vitreous Body / metabolism

Substances

8-Hydroxy-2'-Deoxyguanosine
Deoxyguanosine