Abstract
Background:
Tumor necrosis factor (TNF) inhibitors such as adalimumab are increasingly used in the treatment of ocular inflammatory disease refractory to standard therapies. There is evidence that TNF inhibitors are associated with demyelinating neurologic events.
Objective:
The authors report a case of optic neuritis and multiple sclerosis developing in association with the use of adalimumab for the treatment of bilateral chronic granulomatous iridocyclitis and multifocal choroiditis. They also review the available literature on cases of optic neuritis occurring in the setting of TNF inhibition.
Results:
The authors identified 21 cases of optic neuritis associated with TNF inhibition; 36% of cases with available MRI results had evidence of other demyelinating lesions in the CNS.
Conclusions:
The strong association between TNF inhibitors and CNS demyelination may represent an adverse effect of these drugs. Ophthalmologists should recognize the relationship between TNF inhibitors and demyelinating disease, as it can present initially with visual symptoms.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adalimumab
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Adjuvants, Immunologic / therapeutic use
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Adult
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Anti-Inflammatory Agents / adverse effects*
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Anti-Inflammatory Agents / therapeutic use
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Antibodies, Monoclonal / adverse effects*
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Antibodies, Monoclonal / therapeutic use
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Antibodies, Monoclonal, Humanized
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Brain / pathology
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Drug Administration Schedule
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Female
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Humans
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Injections, Intravenous
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Interferon beta-1a
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Interferon-beta / therapeutic use
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Iridocyclitis / chemically induced*
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Iridocyclitis / diagnosis
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Iridocyclitis / drug therapy
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Iridocyclitis / physiopathology
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Magnetic Resonance Imaging
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Methylprednisolone / administration & dosage
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Multiple Sclerosis / chemically induced*
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Multiple Sclerosis / diagnosis
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Multiple Sclerosis / drug therapy
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Multiple Sclerosis / physiopathology
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Optic Neuritis / chemically induced*
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Optic Neuritis / diagnosis
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Optic Neuritis / drug therapy
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Optic Neuritis / physiopathology
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
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Uveitis / drug therapy*
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Visual Fields
Substances
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Adjuvants, Immunologic
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Anti-Inflammatory Agents
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Tumor Necrosis Factor-alpha
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Interferon-beta
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Adalimumab
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Methylprednisolone
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Interferon beta-1a