Abstract
We retrospectively studied the nuclear RNA content in uveal melanomas with known, long-term follow-up. Thirty patients had spindle cell melanomas, 25 had mixed cell tumors, and 9 had epithelioid cell neoplasms. Epithelioid cell types had a higher nuclear RNA content compared to mixed or spindle cell types (p less than 0.05). Using the Cox proportional hazards model, the nuclear RNA content appeared to be an independent prognostic indicator in uveal melanomas, and an increased nuclear RNA content was associated with a worse prognosis (p = 0.001).
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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DNA, Neoplasm / analysis
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Flow Cytometry
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Follow-Up Studies
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Humans
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Melanoma / analysis*
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Melanoma / classification
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Melanoma / genetics
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Melanoma / mortality
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Neoplasms, Germ Cell and Embryonal / analysis*
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Neoplasms, Germ Cell and Embryonal / genetics
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Neoplasms, Germ Cell and Embryonal / mortality
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Prognosis
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Proportional Hazards Models
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RNA, Neoplasm / analysis*
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RNA, Nuclear / analysis*
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Retrospective Studies
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Risk Factors
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Uveal Neoplasms / analysis*
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Uveal Neoplasms / genetics
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Uveal Neoplasms / mortality
Substances
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DNA, Neoplasm
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RNA, Neoplasm
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RNA, Nuclear