Angiogenic activity of the retina in experimentally induced retinal detachment in cats was examined using the corneal micropocket technique and chorioallantoic membrane assay. The results of these studies indicate that the detached retina possesses higher angiogenic activity than the normal, attached retina. This suggests that disturbances in the nourishment by the choroid of outer retinal layers may play a role in the pathogenesis of ocular neovascularization.