Limb regeneration in salamanders and digital tip regeneration in experimental mice: implications for the hand surgeon

M M Al-Qattan; A M Al-Qattan; D A Al-Maged Ahmed; M M Abd Al-Wahed; M K Shier

doi:10.1177/1753193414526109

Limb regeneration in salamanders and digital tip regeneration in experimental mice: implications for the hand surgeon

J Hand Surg Eur Vol. 2014 Nov;39(9):989-93. doi: 10.1177/1753193414526109. Epub 2014 Mar 11.

Authors

M M Al-Qattan¹, A M Al-Qattan², D A Al-Maged Ahmed³, M M Abd Al-Wahed³, M K Shier³

Affiliations

¹ Division of Plastic Surgery, King Saud University, Riyadh, Saudi Arabia moqattan@hotmail.com.
² Division of Plastic Surgery, King Saud University, Riyadh, Saudi Arabia.
³ College of Medicine Research Center, King Saud University, Riyadh, Saudi Arabia.

PMID: 24619249
DOI: 10.1177/1753193414526109

Abstract

Several lessons and observations from limb regeneration in animals could open new insights to direct related research in the field of hand surgery. This article briefly reviews the biology of limb regeneration in salamanders and experimental mice, with special emphasis on implications for hand surgery.

Level of evidence: 5.

Keywords: hand; mice; nAG; regeneration; salamander.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Animals, Newborn / physiology*
Bone Morphogenetic Protein 4 / physiology
Fetal Development / physiology
Finger Injuries / physiopathology
Finger Injuries / surgery
Forelimb / physiology*
Hindlimb / physiology*
Homeodomain Proteins / physiology
Humans
Limb Buds / drug effects
Limb Buds / physiology
Mice / physiology*
Regeneration / drug effects
Regeneration / physiology*
Species Specificity
Translational Research, Biomedical
Tretinoin / pharmacology
Urodela / physiology*

Substances

Bmp4 protein, mouse
Bone Morphogenetic Protein 4
Homeodomain Proteins
Tretinoin