Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

Affiliations

• ¹ Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany. Electronic address: m.kool@dkfz.de.
• ² Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
• ³ Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
• ⁴ Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA.
• ⁵ Division of Molecular Genetics, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
• ⁶ Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
• ⁷ The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada.
• ⁸ Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
• ⁹ Institut Curie, 75005 Paris, France; Institut Curie/INSERM U830, 75248 Paris, France.
• ¹⁰ Department of Neuropathology, NN Burdenko Neurosurgical Institute, Moscow 125047, Russia.
• ¹¹ European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
• ¹² The Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
• ¹³ Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
• ¹⁴ Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany; Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute (HKI), 07745 Jena, Germany.
• ¹⁵ Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
• ¹⁶ Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; UMR 8203, CNRS Vectorology and Anticancer Therapeutics, Gustave Roussy Cancer Institute, University Paris XI, 94805 Villejuif Cedex, France.
• ¹⁷ Department of Oncogenomics, Academic Medical Center, Amsterdam 1105 AZ, the Netherlands.
• ¹⁸ Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
• ¹⁹ Data Management Facility, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
• ²⁰ Division of Translational Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69121 Heidelberg, Germany.
• ²¹ Department of Oncology, University Hospital Zürich, 8006 Zürich, Switzerland.
• ²² Department of Neuropathology, University of Heidelberg, 69120 Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
• ²³ Cnopf'sche Kinderklinik, Nürnberg Children's Hospital, 90419 Nürnberg, Germany.
• ²⁴ Department of Neuropathology, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
• ²⁵ Institute for Neuropathology, University Hospital Münster, 48149 Münster, Germany.
• ²⁶ Departments of Pediatrics and Neurosciences, University of California San Diego, La Jolla, CA 92093; Rady Children's Hospital, San Diego, CA 92123, USA.
• ²⁷ Division of Pediatric Hematology/Oncology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA; Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
• ²⁸ Departments of Pediatrics and Human Genetics, McGill University Health Centre Research Institute, Montreal, QC H3H 1P3, Canada.
• ²⁹ Departments of Pathology and Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
• ³⁰ Departments of Pathology and Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA 94143, USA.
• ³¹ Department of Neuropathology, The Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, ON M5G 1L7, Canada.
• ³² Institut Curie, 75005 Paris, France; Université Paris Descartes, 75006 Paris, France.
• ³³ Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
• ³⁴ Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.
• ³⁵ Pediatric Medical Neuro-Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA 02215, USA.
• ³⁶ Department of Neurology and Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
• ³⁷ Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
• ³⁸ CCU Pediatric Oncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
• ³⁹ Center for Neuropathology and Prion Research, Ludwig-Maximilians-Universität, 81377 München, Germany.
• ⁴⁰ Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department of Neuropathology, University of Heidelberg, 69120 Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.