Polymorphisms in cytomegalovirus genotype in immunocompetent patients with corneal endotheliitis or iridocyclitis

Naoko Oka; Takashi Suzuki; Tomoyuki Inoue; Takeshi Kobayashi; Yuichi Ohashi

doi:10.1002/jmv.24239

Polymorphisms in cytomegalovirus genotype in immunocompetent patients with corneal endotheliitis or iridocyclitis

J Med Virol. 2015 Aug;87(8):1441-5. doi: 10.1002/jmv.24239. Epub 2015 May 11.

Authors

Naoko Oka¹, Takashi Suzuki¹, Tomoyuki Inoue¹, Takeshi Kobayashi¹, Yuichi Ohashi¹

Affiliation

¹ Department of Ophthalmology, Ehime University Graduate School of Medicine, Japan.

PMID: 25963863
DOI: 10.1002/jmv.24239

Abstract

Cytomegalovirus (CMV) that caused corneal endotheliitis and iridocyclitis in immunocompetent patients was genotyped. The gB type1 was detected in seven endotheliitis samples (77.8%) and five iridocyclitis samples (100%), and the gB type 3 was detected in two endotheliitis samples (22.2%). The UL144 type 1 was found in five endotheliitis samples (45.5%) and five iridocyclitis samples (83.3%). The UL144 type 2 was found in two endotheliitis samples (18.2%) and one iridocyclitis sample (16.7%). The gB type 1 was predominant in endotheliitis and iridocyclitis, and the CMV genotypes in eyes with endotheliitis and iridocyclitis were similar.

Keywords: UL55gB; corneal endotheliitis; cytomegalovirus; genotype; iridocyclitis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Cytomegalovirus / classification*
Cytomegalovirus / genetics*
Cytomegalovirus / isolation & purification
Cytomegalovirus Infections / epidemiology
Cytomegalovirus Infections / virology*
Female
Genetic Variation*
Genotype*
Humans
Iridocyclitis / epidemiology
Iridocyclitis / virology*
Keratitis / epidemiology
Keratitis / virology*
Male
Middle Aged
Molecular Epidemiology
Prevalence