Objective: Genetic disorders enter the differential diagnosis of common neurologic diseases, but their overall prevalence is not known. We set out to determine their minimum prevalence.
Methods: Meta-analysis of epidemiologic data gathered from the same geographic region in the North of England.
Results: Monogenic neurologic disorders affect at least 90.9/100,000 (95% confidence interval 87.6-94.3), or 1 in 1,100 of the population in Northern England.
Conclusion: As a group, neurogenetic disorders are not rare. These findings have implications for clinical service delivery.
© 2015 American Academy of Neurology.