Abstract
Thirty-nine patients with bacterial ocular surface infections (conjunctivitis, blepharitis or blepharoconjunctivitis) were evaluated after treatment with a topically applied ophthalmic solution containing trimethoprim. A combination of trimethoprim and polymixin B (TP) produced identical clinical and microbiologic responses when compared to a solution containing, in addition to trimethoprim and polymyxin B, sulfacetamide. The sulfa component was not essential to produce desired clinical and microbiologic results.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Topical
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Bacterial Infections / drug therapy*
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Clinical Trials as Topic
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Double-Blind Method
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Drug Therapy, Combination
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Eye Diseases / drug therapy*
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Follow-Up Studies
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Humans
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Polymyxin B / administration & dosage
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Polymyxin B / therapeutic use
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Random Allocation
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Sulfacetamide / administration & dosage
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Sulfacetamide / therapeutic use
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Trimethoprim / administration & dosage
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Trimethoprim / therapeutic use*
Substances
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Sulfacetamide
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Trimethoprim
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Polymyxin B