Abstract
A well-recognized complication of ethambutol use is optic neuropathy, but the potential ocular toxicity of isoniazid is often overlooked. A patient developed optic neuropathy while being treated with isoniazid and ethambutol. The optic neuropathy subsided only when both drugs were discontinued, suggesting an additive toxic effect.
MeSH terms
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Aged
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Diabetes Mellitus, Type 2 / complications
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Drug Synergism
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Ethambutol / adverse effects*
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Ethambutol / therapeutic use
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Humans
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Isoniazid / adverse effects*
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Isoniazid / therapeutic use
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Male
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Mycobacterium tuberculosis / isolation & purification
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Optic Disk / pathology*
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Scotoma / chemically induced*
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Tuberculosis, Pulmonary / complications
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Tuberculosis, Pulmonary / drug therapy