The Microruptor II (MR-II) Nd:YAG laser developed by Fankhauser was evaluated in a national multicenter prospective study of posterior capsulotomy. Results are reported on 3,711 patients who underwent Nd:YAG laser photodiscission. Ninety-two percent of patients experienced an improvement in vision at some point following photodiscission and the postoperative complications of persistent cystoid macular edema and glaucoma occurred at rates of 2.5% and 0.2%, respectively, indicating the safety and efficacy of the MR-II for posterior capsulotomy.