Abstract
Amphotericin B, 5-flucytosine (5-FC), and ketoconazole levels were estimated in vitreous and aqueous samples taken from four patients undergoing therapeutic vitrectomy for fungal endophthalmitis. The levels of amphotericin B in the vitreous of three patients were low (.04 - .17 microgram/ml). However, 5-FC was present in a concentration of 22.2 micrograms/ml in one patient. In another case the aqueous level of ketoconazole was 0.35 microgram/ml. The vitreous in the same patient contained 0.71 microgram/ml of the drug.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amphotericin B / administration & dosage
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Antifungal Agents / administration & dosage*
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Antifungal Agents / metabolism
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Antifungal Agents / therapeutic use
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Candidiasis / drug therapy
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Cataract Extraction / adverse effects
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Drug Contamination
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Eye / metabolism*
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Flucytosine / administration & dosage
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Humans
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Ketoconazole / administration & dosage
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Orbital Diseases / drug therapy
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Postoperative Complications
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Therapeutic Irrigation / adverse effects
Substances
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Antifungal Agents
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Amphotericin B
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Flucytosine
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Ketoconazole