The safety and efficacy of sodium hyaluronate (Healon) was evaluated in a wide spectrum of anterior segment surgical procedures. Healon is not only safe, but actually facilitates the outcome of surgery. Healon placed intracamerally before cataract removal results in significantly decreased endothelial cell loss. In filtering procedures, use of intracameral and subconjunctival Healon promotes superior bleb formation while still maintaining chamber depth postoperatively. Corneal grafts performed over intracameral Healon receive maximal endothelial protection and manifest striking postoperative clarity.