19 patients showing the features of diffuse retinal pigment epitheliopathy, as described by Zweng and Little, were studied. Diffuse retinal pigment epitheliopathy resembles both pigment epithelial detachment and central nervous choriopathy, but can be differentiated by the following characteristic features: widespread distribution of small pigment epithelial detachments, little or no leakage visible on the fluorescence angiogram, extensive pigmentary changes, chronic course with exacerbations and remissions, and fair visual prognosis.