Previous studies have stressed the benefit of laser photocoagulation for patients with age-related macular degeneration (AMD) and well-defined subretinal neovascularization (SRN). However, such lesions account for only 30% of cases with exudative age-related maculopathy. Especially in patients with retinal pigment epithelial detachment (PED), SRN is usually occult. This study was performed to reveal the role of digital indocyanine green (ICG) video angiography in the diagnosis of SRN in patients with PED. A total of 34 patients with AMD-associated retinal PED participated in the current study and underwent fluorescein and ICG angiography using scanning laser ophthalmoscopy. In these patients fluorescein angiography revealed no distinct SRN, whereas in 21 eyes (62%) ICG angiography showed well-demarcated choroidal neovascularization. The present study demonstrates that SRN can be detected in more than 50% of patients with PED by means of ICG video angiography. Therefore, ICG video angiography improves the detection of SRN in patients with AMD-associated PED.