Abstract
During a successful immune response, several families of adhesion molecules participate in a cascade of binding events that lead to the binding of leukocytes, both to each other and to cell types such as the endothelium and epithelium. A central theme emerging from recent studies is that the function of an adhesion receptor cannot be inferred from its expression alone; rather, adhesion receptors are 'selected' to perform distinct effector functions based on their cell-background and factors present in the local microenvironment. Thus, adhesion receptors expressed on different cell-types may find themselves in different states of 'activation-readiness' and may be further selected by prevailing conditions in the microenvironment to bind tissue-specific ligands and mediate leukocyte effector functions such as homing or transendothelial migration.
MeSH terms
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Animals
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Antibodies / therapeutic use
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Antibodies, Monoclonal / immunology
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Antigens, Neoplasm / physiology
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Cadherins / physiology
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Cell Adhesion
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Cell Adhesion Molecules / classification
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Cell Adhesion Molecules / immunology
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Cell Adhesion Molecules / physiology*
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E-Selectin
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Humans
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Integrins / physiology
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Intercellular Adhesion Molecule-1
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L-Selectin
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Lectins / physiology
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Ligands
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Lymphocyte Function-Associated Antigen-1 / immunology
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Lymphocytes / immunology*
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Mice
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Multigene Family
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P-Selectin
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Platelet Membrane Glycoproteins / physiology
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Protein-Tyrosine Kinases / physiology
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Receptors, Immunologic / physiology
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Receptors, Lymphocyte Homing / physiology
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Signal Transduction
Substances
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Antibodies
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Antibodies, Monoclonal
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Antigens, Neoplasm
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Cadherins
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Cell Adhesion Molecules
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E-Selectin
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Integrins
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Lectins
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Ligands
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Lymphocyte Function-Associated Antigen-1
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P-Selectin
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Platelet Membrane Glycoproteins
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Receptors, Immunologic
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Receptors, Lymphocyte Homing
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integrin alphaEbeta7
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Intercellular Adhesion Molecule-1
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L-Selectin
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Protein-Tyrosine Kinases