Bilateral spastic cerebral palsy--MRI pathology and origin. Analysis from a representative series of 56 cases

Dev Med Child Neurol. 1995 May;37(5):379-97. doi: 10.1111/j.1469-8749.1995.tb12022.x.

Abstract

MRI of the brain was performed on 56 children with bilateral spastic cerebral palsy (CP) at a mean age of 10.7 years. Specific pathology was found in 91 per cent; periventricular leukomalacia was present in 42 per cent of term- and 87 per cent of preterm-born children. Parasagittal subcorticocortical injury, multicystic encephalomalacia and basal ganglia lesions were identified in 16 per cent, in all but one associated with severe peri-/neonatal events at term or near term. Maldevelopment comprised 9 per cent, all but one found in term-born children. MRI morphology correlated strikingly with outcome. Periventricular leukomalacia was associated with more severe disability in term- than preterm-born children.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Brain / pathology*
  • Brain / physiopathology
  • Cerebral Palsy / pathology*
  • Cerebral Palsy / physiopathology
  • Child
  • Child, Preschool
  • Female
  • Functional Laterality
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Muscle Spasticity / pathology
  • Muscle Spasticity / physiopathology
  • Risk Factors
  • Severity of Illness Index