Abstract
The penetration into the eye of fluorescein from a normal drop was found to increase with age and averaged twelve times more in the elderly than in the young. Examination of the literature suggests that this is a result of a greater contact time with the cornea rather than a rise in epithelial permeability.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Aging / physiology*
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Cell Membrane Permeability
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Cornea / metabolism
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Epithelium / metabolism
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Eye / metabolism*
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Female
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Fluorescein
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Fluoresceins / pharmacokinetics*
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Humans
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Male
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Middle Aged
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Ophthalmic Solutions
Substances
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Fluoresceins
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Ophthalmic Solutions
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Fluorescein