Creutzfeldt-Jakob disease transmitted by a cadaveric dura mater graft

Neurosurgery. 1994 Apr;34(4):740-3; discussion 743-4. doi: 10.1227/00006123-199404000-00027.

Abstract

We report a case of Creutzfeldt-Jakob disease developing in a 31-year-old woman 56 months after she received a cadaveric dura mater graft after the removal of a giant pituitary adenoma. Creutzfeldt-Jakob disease was confirmed by a brain autopsy and the existence of an abnormal isoform of prion protein, verified by both immunohistochemical and Western blot analysis. Moreover, prion protein gene analysis was shown in this case to possess a wild-type genotype. The characteristics of Creutzfeldt-Jakob disease after a cadaveric dura mater graft are reviewed and discussed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenoma / pathology
  • Adenoma / surgery*
  • Adult
  • Blotting, Western
  • Brain / pathology
  • Collagen / adverse effects*
  • Craniotomy*
  • Creutzfeldt-Jakob Syndrome / diagnosis
  • Creutzfeldt-Jakob Syndrome / genetics
  • Creutzfeldt-Jakob Syndrome / pathology
  • Creutzfeldt-Jakob Syndrome / transmission*
  • Fatal Outcome
  • Female
  • Follow-Up Studies
  • Growth Hormone / metabolism*
  • Humans
  • Magnetic Resonance Imaging
  • Neurologic Examination
  • Pituitary Neoplasms / pathology
  • Pituitary Neoplasms / surgery*
  • Postoperative Complications / diagnosis*
  • Postoperative Complications / pathology
  • Prions / genetics

Substances

  • Lyodura
  • Prions
  • Growth Hormone
  • Collagen