Four cases of incisional complications following pars plana vitrectomy are presented. In each instance, excessive fibrosis occurred at the wound site. In one patient, the disorder was mild and did not lead to clinical difficulties during his lifetime, however, in the three severe cases the eyes were lost secondary to intraocular organization and phthisis bulbi. Possible contributing factors include diabetes mellitus, excessive trauma and necrosis at the wound site, postoperative inflammation, and vitreous involvement in the wound. Since no treatment is known, atraumatic management of the incision using microsurgical techniques is strongly recommended.