Abstract
Background:
Although intravitreal aminoglycosides have substantially improved visual prognosis in endophthalmitis, macular infarction may impair full visual recovery.
Methods:
We present a case of presumed amikacin retinal toxicity following treatment with amikacin and vancomycin for alpha-haemolytic streptococcal endophthalmitis.
Results:
Endophthalmitis resolved with improvement in visual acuity to 6/24 at three months. Fundus fluorescein angiography confirmed macular capillary closure and telangiectasis.
Conclusions:
Currently accepted intravitreal antibiotic regimens may cause retinal toxicity and macular ischaemia. Treatment strategies aimed at avoiding retinal toxicity are discussed.
MeSH terms
-
Adolescent
-
Amikacin / administration & dosage
-
Amikacin / adverse effects*
-
Anti-Bacterial Agents / administration & dosage
-
Anti-Bacterial Agents / adverse effects*
-
Endophthalmitis / diagnosis
-
Endophthalmitis / drug therapy
-
Endophthalmitis / microbiology
-
Eye Infections, Bacterial / diagnosis
-
Eye Infections, Bacterial / drug therapy
-
Eye Infections, Bacterial / etiology
-
Fluorescein Angiography
-
Fundus Oculi
-
Humans
-
Injections
-
Lens, Crystalline / surgery
-
Macula Lutea / blood supply
-
Macula Lutea / drug effects*
-
Macula Lutea / pathology
-
Male
-
Retinal Vessels / drug effects*
-
Streptococcal Infections / diagnosis
-
Streptococcal Infections / drug therapy
-
Streptococcal Infections / etiology
-
Streptococcus
-
Telangiectasis / chemically induced*
-
Telangiectasis / pathology
-
Vitrectomy
-
Vitreous Body / drug effects*
Substances
-
Anti-Bacterial Agents
-
Amikacin