Purpose: To report two cases in which cystoid macular edema developed after initiation of topical latanoprost for glaucoma.
Methods: Case reports. One pseudophakic eye in each of two patients treated with latanoprost for glaucoma developed decreased vision and cystoid macular edema. Latanoprost was discontinued, and the cystoid macular edema was treated with topical corticosteroids and ketorolac.
Results: After discontinuing latanoprost and starting corticosteroids and ketorolac, visual acuity improved from counting fingers to 20/60 in one patient's left eye and from 20/100 to 20/25 in the other patient's right eye. The macular edema resolved in both eyes.
Conclusions: Topical latanoprost may be associated with cystoid macular edema; this may be related to a prostaglandin-like action.