Ceftriaxone diffusion from blood to aqueous humour in man

Br J Ophthalmol. 1989 Jul;73(7):574-5. doi: 10.1136/bjo.73.7.574.

Abstract

Ceftriaxone penetrates into the aqueous humour in man. The interaction of indomethacin on the disposition of ceftriaxone appeared to be time-dependent. Indomethacin delayed ceftriaxone penetration into, but enhanced its persistence in, the aqueous humour, permitting a period of antibioprophylaxis covering the required time for surgical treatment.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aqueous Humor / metabolism*
  • Ceftriaxone / blood
  • Ceftriaxone / pharmacokinetics*
  • Diffusion
  • Drug Interactions
  • Female
  • Humans
  • Indomethacin / pharmacology
  • Male
  • Middle Aged

Substances

  • Ceftriaxone
  • Indomethacin