Myopia

…, KO Matsui, PC Wu, P Sankaridurg, A Chia… - Nature reviews Disease …, 2020 - nature.com
Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

Dual role of autophagy in hallmarks of cancer

SS Singh, S Vats, AYQ Chia, TZ Tan, S Deng, MS Ong… - Oncogene, 2018 - nature.com
Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an
intracellular catabolic degradative process targeting damaged and superfluous cellular …

[HTML][HTML] IMI–interventions for controlling myopia onset and progression report

CF Wildsoet, A Chia, P Cho… - … & visual science, 2019 - iovs.arvojournals.org
Myopia has been predicted to affect approximately 50% of the world's population based on
trending myopia prevalence figures. Critical to minimizing the associated adverse visual …

[HTML][HTML] SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

…, AT Tan, K Kunasegaran, CYL Tham, M Hafezi, A Chia… - Nature, 2020 - nature.com
Memory T cells induced by previous pathogens can shape susceptibility to, and the clinical
severity of, subsequent infections. Little is known about the presence in humans of pre …

Atropine for the treatment of childhood myopia: safety and efficacy of 0.5%, 0.1%, and 0.01% doses (Atropine for the Treatment of Myopia 2)

A Chia, WH Chua, YB Cheung, WL Wong, A Lingham… - Ophthalmology, 2012 - Elsevier
PURPOSE: Our previous study, Atropine for the Treatment of Myopia 1 (ATOM1), showed
that atropine 1% eyedrops were effective in controlling myopic progression but with visual …

[PDF][PDF] Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

…, K Kunasegaran, Y Zhuang, CYL Tham, A Chia… - Cell reports, 2021 - cell.com
Virus-specific humoral and cellular immunity act synergistically to protect the host from viral
infection. We interrogate the dynamic changes of virological and immunological parameters …

Outdoor activity and myopia in Singapore teenage children

…, L Tong, G Gazzard, X Zhang, A Chia… - British Journal of …, 2009 - bjo.bmj.com
Aim: To investigate the relationship of outdoor activities and myopia in Singapore teenage
children. Methods: Teenage children (1249 participants), examined in the Singapore Cohort …

Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

…, ZM Tun, V Kumar, BL Lim, SH Lim, A Chia… - Journal of Experimental …, 2021 - rupress.org
The efficacy of virus-specific T cells in clearing pathogens involves a fine balance between
antiviral and inflammatory features. SARS-CoV-2–specific T cells in individuals who clear …

Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection

OW Ng, A Chia, AT Tan, RS Jadi, HN Leong… - Vaccine, 2016 - Elsevier
Severe acute respiratory syndrome (SARS) is a highly contagious infectious disease which
first emerged in late 2002, caused by a then novel human coronavirus, SARS coronavirus …

Five-year clinical trial on atropine for the treatment of myopia 2: myopia control with atropine 0.01% eyedrops

A Chia, QS Lu, D Tan - Ophthalmology, 2016 - Elsevier
Purpose To compare the safety and efficacy of different concentrations of atropine eyedrops
in controlling myopia progression over 5 years. Design Randomized, double-masked …