Phospholipid bilayer Nanodiscs are novel model membranes derived from high-density
lipoprotein particles and have proven to be useful in studies of membrane proteins …

The small molecule thioflavin T (ThT) is a defining probe for the identification and
mechanistic study of amyloid fiber formation. As such, ThT is fundamental to investigations of …

Intrinsically disordered proteins (IDPs) are increasingly recognized for their important roles
in a range of biological contexts, both in normal physiological function and in a variety of …

The microtubule-associated protein tau forms insoluble, amyloid-type aggregates in various
dementias, most notably Alzheimer's disease. Cellular chaperone proteins play important …

Catalytic promiscuity is a widespread, but poorly understood, phenomenon among enzymes
with particular relevance to the evolution of new functions, drug metabolism, and in vitro …

Tau is an intrinsically disordered protein with an important role in maintaining the dynamic
instability of neuronal microtubules. Despite intensive study, a detailed understanding of the …

The membrane-bound protein cytochrome P450 3A4 (CYP3A4) is a major drug-
metabolizing enzyme. Most studies of ligand binding by CYP3A4 are currently carried out in …

Small heat shock proteins (sHSPs) are nature's 'first responders' to cellular stress, interacting
with affected proteins to prevent their aggregation. Little is known about sHSP structure …

Small heat shock proteins (sHSPs) are a class of ATP-independent molecular chaperones
that play vital roles in maintaining protein solubility and preventing aberrant protein …

The structurally related glutathione S-transferase isoforms GSTA1-1 and GSTA4-4 differ
greatly in their relative catalytic promiscuity. GSTA1-1 is a highly promiscuous detoxification …