Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal …
The retinal and cerebral microvasculatures share many morphological and physiological
properties. Assessment of the cerebral microvasculature requires highly specialized and …
properties. Assessment of the cerebral microvasculature requires highly specialized and …
[HTML][HTML] DNA methylation age of blood predicts all-cause mortality in later life
Background DNA methylation levels change with age. Recent studies have identified
biomarkers of chronological age based on DNA methylation levels. It is not yet known …
biomarkers of chronological age based on DNA methylation levels. It is not yet known …
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a …
because of limitations on sample size in previous studies. Subjective well-being, a …
[HTML][HTML] Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …
with many important life outcomes. We combine cognitive and genetic data from the …
[HTML][HTML] Brain age predicts mortality
Age-associated disease and disability are placing a growing burden on society. However,
ageing does not affect people uniformly. Hence, markers of the underlying biological ageing …
ageing does not affect people uniformly. Hence, markers of the underlying biological ageing …
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
HR Warren, E Evangelou, CP Cabrera, H Gao, M Ren… - Nature …, 2017 - nature.com
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse …
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse …
The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936
Background: The DNA methylation-based 'epigenetic clock'correlates strongly with
chronological age, but it is currently unclear what drives individual differences. We examine …
chronological age, but it is currently unclear what drives individual differences. We examine …
Goldberg's 'IPIP'Big-Five factor markers: Internal consistency and concurrent validation in Scotland
Goldberg's (2001) IPIP Big-Five personality factor markers currently lack validating
evidence. The structure of the 50-item IPIP was examined in three different adult samples …
evidence. The structure of the 50-item IPIP was examined in three different adult samples …
[HTML][HTML] Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N= 53 949)
General cognitive function is substantially heritable across the human life course from
adolescence to old age. We investigated the genetic contribution to variation in this …
adolescence to old age. We investigated the genetic contribution to variation in this …
Cohort profile: the Lothian Birth Cohorts of 1921 and 1936
This cohort profile describes the origins, tracing, recruitment, testing and follow-up of the
University of Edinburgh-based Lothian Birth Cohorts of 1921 (LBC1921; N= 550) and 1936 …
University of Edinburgh-based Lothian Birth Cohorts of 1921 (LBC1921; N= 550) and 1936 …