Vernal keratoconjunctivitis

A Leonardi, AG Secchi - International ophthalmology clinics, 2003 - journals.lww.com
Vernal keratoconjunctivitis (VKC) is a relatively rare, chronic form of ocular allergy that can
cause severe visual complications. It is most often seen in male persons up to 25 years of …

Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis

AG Secchi, MS Tognon, A Leonardi - American journal of ophthalmology, 1990 - Elsevier
We treated 11 patients with vernal keratoconjunctivitis for four to nine months with topical
cyclosporine as a 2% dilution in castor oil. No significant side effects occurred, except for …

Case series of 406 vernal keratoconjunctivitis patients: a demographic and epidemiological study

A Leonardi, F Busca, L Motterle… - Acta …, 2006 - Wiley Online Library
Purpose: To evaluate the specific allergic sensitization and epidemiological characteristics
of vernal keratoconjunctivitis (VKC). Methods: This retrospective non‐comparative case …

[HTML][HTML] Tear levels and activity of matrix metalloproteinase (MMP)-1 and MMP-9 in vernal keratoconjunctivitis

A Leonardi, P Brun, G Abatangelo… - … & visual science, 2003 - arvojournals.org
purpose. To study levels and activity of matrix metalloproteinase (MMP)-1 and-9 and their
tissue inhibitor (TIMP-1) in tears of patients with vernal keratoconjunctivitis (VKC), with and …

Tear and serum soluble leukocyte activation markers in conjunctival allergic diseases

A Leonardi, F Borghesan, D Faggian, M DePaoli… - American journal of …, 2000 - Elsevier
PURPOSE: To measure markers of leukocyte activation in patients with an exclusively
ocular inflammatory or bacterial disease. METHODS: Neutrophil myeloperoxidase …

Th1-and Th2-type cytokines in chronic ocular allergy

A Leonardi, IA Fregona, M Plebani, AG Secchi… - Graefe's Archive for …, 2006 - Springer
Background Previous reports have suggested that Th2-type cytokines are important in the
pathogenesis of ocular allergic diseases. The purpose of this study is to measure levels and …

[HTML][HTML] Identification of local Th2 and Th0 lymphocytes in vernal conjunctivitis by cytokine flow cytometry

A Leonardi, G DeFranchis, F Zancanaro… - … & visual science, 1999 - arvojournals.org
purpose. Th2 lymphocytes may play a key role in the development of allergic diseases such
as vernal keratoconjunctivitis (VKC). Cytokine flow cytometry of tear samples was used to …

[HTML][HTML] Effects of Th2 cytokines on expression of collagen, MMP-1, and TIMP-1 in conjunctival fibroblasts

A Leonardi, R Cortivo, I Fregona… - … & visual science, 2003 - iovs.arvojournals.org
purpose. To determine whether cytokines involved in chronic allergic conjunctival disorders
may affect formation of giant papillae and tissue remodeling. methods. Conjunctival …

Histamine effects on conjunctival fibroblasts from patients with vernal conjunctivitis

A Leonardi, M RADICE, IVAA FREGONA… - Experimental eye …, 1999 - Elsevier
Histamine, an important mast cell mediator in allergic disorders, may affect extracellular
matrix production and cell growth in vernal keratoconjunctivitis (VKC). In the present study …

Effects of cyclosporin A on human conjunctival fibroblasts

A Leonardi, G DeFranchis, IA Fregona… - Archives of …, 2001 - jamanetwork.com
Objective To evaluate the effects of cyclosporin A (CsA) on cytokine and/or collagen
production, cell growth, and apoptosis in conjunctival fibroblast cultures. Methods Fibroblast …