Diabetes carries a high risk of athero-sclerosis, and cardiovascular disease, especially
coronary heart disease (CHD) and stroke, is by far the leading cause of death among …

BACKGROUND & AIMS: The identification of the cellular and molecular pathways that
mediate the development of non-alcoholic steatohepatitis is of crucial importance. Cytokines …

When grown under defined conditions Dunaliella bardawil accumulates a high
concentration of β-carotene, which is composed primarily of two isomers, all-trans and 9-cis …

The role of the immune system in modulating atherosclerosis has recently been the subject
of intensive research. Several previous authors have put forward a paradigm of the …

To study the possible role of the human lipid-oxidizing enzyme 15-lipoxygenase (15-LO) in
atherosclerosis, we overexpressed it specifically in the vascular wall of C57B6/SJL mice by …

Preeclampsia and intrauterine growth restriction (IUGR) are pregnancy-specific disorders
that share a common pathophysiology. Hypoxia-inducible factor-1α (HIF-1α) is a …

Background Human 15-lipoxygenase (LO) and its murine analogue 12/15-LO are capable of
directly oxidizing esterified fatty acids in lipoproteins and phospholipids. Because these …

Recent data suggest that the immune system is involved in atherogenesis. Thus, interest has
been raised as to the possible antigens that could serve as the initiators of the immune …

Background—Immunization with β2-glycoprotein I (β2GPI), the probable target of
autoimmune anticardiolipin antibodies, results in experimental antiphospholipid syndrome …

Background—It has been proposed that autoimmune factors can influence the progression
of atherosclerosis. We have previously shown that immunization of LDL receptor–deficient …