[HTML][HTML] Retinoblastoma

H Dimaras, K Kimani, EAO Dimba, P Gronsdahl… - The Lancet, 2012 - thelancet.com
Retinoblastoma is an aggressive eye cancer of infancy and childhood. Survival and the
chance of saving vision depend on severity of disease at presentation. Retinoblastoma was …

Retinoblastoma

H Dimaras, TW Corson, D Cobrinik, A White… - Nature reviews Disease …, 2015 - nature.com
Retinoblastoma is a rare cancer of the infant retina that is diagnosed in approximately 8,000
children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are …

One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma

TW Corson, BL Gallie - Genes, Chromosomes and Cancer, 2007 - Wiley Online Library
The childhood eye cancer retinoblastoma is initiated by the loss of both alleles of the
prototypic tumor suppressor gene, RB1. However, a large number of cytogenetic and …

Active surveillance of small renal masses: progression patterns of early stage kidney cancer

MAS Jewett, K Mattar, J Basiuk, CG Morash, SE Pautler… - European urology, 2011 - Elsevier
Background Most early stage kidney cancers are renal cell carcinomas (RCCs), and most
are diagnosed incidentally by imaging as small renal masses (SRMs). Indirect evidence …

Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma

MD Onken, LA Worley, DH Char, JJ Augsburger… - Ophthalmology, 2012 - Elsevier
PURPOSE: This study evaluates the prognostic performance of a 15 gene expression
profiling (GEP) assay that assigns primary posterior uveal melanomas to prognostic …

Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy

BL Gallie, A Budning, G DeBoer… - Archives of …, 1996 - jamanetwork.com
Background: External beam radiotherapy is standard treatment for medium and large, or
visually threatening, intraocular retinoblastoma but markedly increases the risk of cosmetic …

[HTML][HTML] Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies

DE Rushlow, BM Mol, JY Kennett, S Yee… - The lancet …, 2013 - thelancet.com
Background Retinoblastoma is the childhood retinal cancer that defined tumour-suppressor
genes. Previous work shows that mutation of both alleles of the RB1 retinoblastoma …

Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition.

MF Hansen, A Koufos, BL Gallie… - Proceedings of the …, 1985 - National Acad Sciences
Survivors of the heritable form of retinoblastoma subsequently develop second primary
osteosarcomas at substantially greater frequency than either the general population or …

Using expression profiling data to identify human microRNA targets

JC Huang, T Babak, TW Corson, G Chua, S Khan… - Nature …, 2007 - nature.com
We demonstrate that paired expression profiles of microRNAs (miRNAs) and mRNAs can be
used to identify functional miRNA-target relationships with high precision. We used a …

Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastoma

H Dimaras, V Khetan, W Halliday, M Orlic… - Human molecular …, 2008 - academic.oup.com
Retinoblastoma clinical observations revealed the role of tumor suppressor genes in human
cancer, Knudson's 'two-hit'model of cancer induction. We now demonstrate that loss of both …