[HTML][HTML] Retinoblastoma
Retinoblastoma is an aggressive eye cancer of infancy and childhood. Survival and the
chance of saving vision depend on severity of disease at presentation. Retinoblastoma was …
chance of saving vision depend on severity of disease at presentation. Retinoblastoma was …
Retinoblastoma
Retinoblastoma is a rare cancer of the infant retina that is diagnosed in approximately 8,000
children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are …
children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are …
One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma
The childhood eye cancer retinoblastoma is initiated by the loss of both alleles of the
prototypic tumor suppressor gene, RB1. However, a large number of cytogenetic and …
prototypic tumor suppressor gene, RB1. However, a large number of cytogenetic and …
Active surveillance of small renal masses: progression patterns of early stage kidney cancer
MAS Jewett, K Mattar, J Basiuk, CG Morash, SE Pautler… - European urology, 2011 - Elsevier
Background Most early stage kidney cancers are renal cell carcinomas (RCCs), and most
are diagnosed incidentally by imaging as small renal masses (SRMs). Indirect evidence …
are diagnosed incidentally by imaging as small renal masses (SRMs). Indirect evidence …
Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma
MD Onken, LA Worley, DH Char, JJ Augsburger… - Ophthalmology, 2012 - Elsevier
PURPOSE: This study evaluates the prognostic performance of a 15 gene expression
profiling (GEP) assay that assigns primary posterior uveal melanomas to prognostic …
profiling (GEP) assay that assigns primary posterior uveal melanomas to prognostic …
Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy
BL Gallie, A Budning, G DeBoer… - Archives of …, 1996 - jamanetwork.com
Background: External beam radiotherapy is standard treatment for medium and large, or
visually threatening, intraocular retinoblastoma but markedly increases the risk of cosmetic …
visually threatening, intraocular retinoblastoma but markedly increases the risk of cosmetic …
[HTML][HTML] Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies
DE Rushlow, BM Mol, JY Kennett, S Yee… - The lancet …, 2013 - thelancet.com
Background Retinoblastoma is the childhood retinal cancer that defined tumour-suppressor
genes. Previous work shows that mutation of both alleles of the RB1 retinoblastoma …
genes. Previous work shows that mutation of both alleles of the RB1 retinoblastoma …
Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition.
MF Hansen, A Koufos, BL Gallie… - Proceedings of the …, 1985 - National Acad Sciences
Survivors of the heritable form of retinoblastoma subsequently develop second primary
osteosarcomas at substantially greater frequency than either the general population or …
osteosarcomas at substantially greater frequency than either the general population or …
Using expression profiling data to identify human microRNA targets
We demonstrate that paired expression profiles of microRNAs (miRNAs) and mRNAs can be
used to identify functional miRNA-target relationships with high precision. We used a …
used to identify functional miRNA-target relationships with high precision. We used a …
Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastoma
Retinoblastoma clinical observations revealed the role of tumor suppressor genes in human
cancer, Knudson's 'two-hit'model of cancer induction. We now demonstrate that loss of both …
cancer, Knudson's 'two-hit'model of cancer induction. We now demonstrate that loss of both …