[HTML][HTML] Diabetic retinopathy: a position statement by the American Diabetes Association

SD Solomon, E Chew, EJ Duh, L Sobrin, JK Sun… - Diabetes …, 2017 - ncbi.nlm.nih.gov
Diabetic retinopathy diagnostic assessment and treatment options have improved
dramatically since the 2002 American Diabetes Association Position Statement (1). These …

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

PH Maxwell, MS Wiesener, GW Chang, SC Clifford… - Nature, 1999 - nature.com
Abstract Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia,
including the regulation of genes involved in energy metabolism, angiogenesis and …

Optimizing anti-VEGF treatment outcomes for patients with neovascular age-related macular degeneration

CC Wykoff, WL Clark, JS Nielsen, JV Brill… - Journal of managed …, 2018 - jmcp.org
BACKGROUND: The introduction of anti-vascular endothelial growth factor (anti-VEGF)
drugs to ophthalmology has revolutionized the treatment of neovascular age-related …

Hypoxia-inducible expression of tumor-associated carbonic anhydrases

CC Wykoff, NJP Beasley, PH Watson, KJ Turner… - Cancer research, 2000 - AACR
The transcriptional complex hypoxia-inducible factor-1 (HIF-1) has emerged as an important
mediator of gene expression patterns in tumors, although the range of responding genes is …

Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE) …

CC Wykoff, F Abreu, AP Adamis, K Basu… - The Lancet, 2022 - thelancet.com
Background To reduce treatment burden and optimise patient outcomes in diabetic macular
oedema, we present 1-year results from two phase 3 trials of faricimab, a novel angiopoietin …

[HTML][HTML] The angiopoietin/tie pathway in retinal vascular diseases: a review

JS Heier, RP Singh, CC Wykoff, KG Csaky, TYY Lai… - Retina, 2021 - journals.lww.com
Purpose: To provide a concise overview for ophthalmologists and practicing retina
specialists of available clinical evidence of manipulating the angiopoietin/tyrosine kinase …

[PDF][PDF] HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

SJ Mandriota, KJ Turner, DR Davies, PG Murray… - Cancer cell, 2002 - cell.com
Mutations in the von Hippel-Lindau (VHL) gene are associated with hereditary and sporadic
clear cell renal carcinoma. VHL acts in a ubiquitin ligase complex regulating hypoxia …

[PDF][PDF] Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma

SK Chia, CC Wykoff, PH Watson, C Han… - Journal of Clinical …, 2001 - researchgate.net
Purpose: To assess the frequency of expression and the prognostic significance of a
hypoxia-regulated marker, carbonic anhydrase IX (CA IX), in a cohort of patients with …

Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer

A Giatromanolaki, MI Koukourakis, E Sivridis… - Cancer research, 2001 - AACR
Abstract Carbonic anhydrase-9 (CA9), a transmembrane enzyme with an extracellular active
site, is involved in the reversible metabolism of the carbon dioxide to carbonic acid. Up …

[HTML][HTML] Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial

DS Liao, FV Grossi, D El Mehdi, MR Gerber, DM Brown… - Ophthalmology, 2020 - Elsevier
Purpose Geographic atrophy (GA), a late stage of age-related macular degeneration (AMD),
is a major cause of blindness. Even while central visual acuity remains relatively well …