Hereditary breast and ovarian cancer syndromes can be caused by loss-of-function
germline mutations in one of two tumour-suppressor genes, BRCA1 and BRCA2 (ref.). Each …

Numerous studies have been published that attempted to correlate fructan concentrations
with freezing and drought tolerance. Studies investigating the effect of fructan on liposomes …

BRCA1 and BRCA2 are tumor suppressor genes, familial mutations in which account for∼
5% of breast cancer cases in the USA annually. Germ line mutations in BRCA1 that truncate …

The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are
aggressive and respond poorly to standard therapies. Although the identification of specific …

It is now clear that members of the ICE/CED-3 protease family play key biological roles in
inflammation and mammalian apoptosis. To date, ten homologs of human origin have been …

BRCA1 immunostaining reveals discrete, nuclear foci during S phase of the cell cycle.
Human Rad51, a homolog of bacterial RecA, behaves similarly. The two proteins were …

Monkey cells synthesizing SV40 large T antigen were lysed and the extracts
immunoprecipitated with either monoclonal anti-T antibody or monoclonal antibody to~ 110 …

The interleukin-1β (IL-1β) converting enzyme (ICE) processes the inactive IL-1β precursor to
the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE …

The growth-controlling functions of the adenovirus E1A oncoprotein depend on its ability ot
interact with a set of cellular proteins. Among these are the retinoblastoma protein, p107 …

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that is critical for
hypoxic induction of a number of physiologically important genes. We present evidence that …