User profiles for "author:Davide Moi"
Davide MoiUniversity of Modena and Reggio Emilia Verified email at unimore.it Cited by 537 |
Hydroxamic acid derivatives: From synthetic strategies to medicinal chemistry applications
Since the approval of three hydroxamic acid-based HDAC inhibitors as anticancer drugs,
such functional groups acquired even more notoriety in synthetic medicinal chemistry. The …
such functional groups acquired even more notoriety in synthetic medicinal chemistry. The …
[HTML][HTML] Recent advances in SARS-CoV-2 main protease inhibitors: from nirmatrelvir to future perspectives
A Citarella, A Dimasi, D Moi, D Passarella, A Scala… - Biomolecules, 2023 - mdpi.com
The main protease (Mpro) plays a pivotal role in the replication of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target …
syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target …
[PDF][PDF] Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells
R Mazzieri, F Pucci, D Moi, E Zonari, A Ranghetti… - Cancer cell, 2011 - cell.com
Tumor-infiltrating myeloid cells convey proangiogenic programs that counteract the efficacy
of antiangiogenic therapy. Here, we show that blocking angiopoietin-2 (ANG2), a TIE2 …
of antiangiogenic therapy. Here, we show that blocking angiopoietin-2 (ANG2), a TIE2 …
Targeted genome editing in human repopulating haematopoietic stem cells
Targeted genome editing by artificial nucleases has brought the goal of site-specific
transgene integration and gene correction within the reach of gene therapy. However, its …
transgene integration and gene correction within the reach of gene therapy. However, its …
A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood “resident” monocytes, and embryonic macrophages suggests common …
F Pucci, MA Venneri, D Biziato, A Nonis… - Blood, The Journal …, 2009 - ashpublications.org
We previously showed that Tie2-expressing monocytes (TEMs) have nonredundant
proangiogenic activity in tumors. Here, we compared the gene expression profile of tumor …
proangiogenic activity in tumors. Here, we compared the gene expression profile of tumor …
[PDF][PDF] Tumor-targeted interferon-α delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis
The use of type I interferons (IFNs) in cancer therapy has been limited by ineffective dosing
and significant toxicity. Here, we exploited the tumor-homing ability of proangiogenic Tie2 …
and significant toxicity. Here, we exploited the tumor-homing ability of proangiogenic Tie2 …
[PDF][PDF] miR-511-3p modulates genetic programs of tumor-associated macrophages
Expression of the mannose receptor (MRC1/CD206) identifies macrophage subtypes, such
as alternatively activated macrophages (AAMs) and M2-polarized tumor-associated …
as alternatively activated macrophages (AAMs) and M2-polarized tumor-associated …
[PDF][PDF] Endocytosis inhibition in humans to improve responses to ADCC-mediating antibodies
A safe and controlled manipulation of endocytosis in vivo may have disruptive therapeutic
potential. Here, we demonstrate that the anti-emetic/anti-psychotic prochlorperazine can be …
potential. Here, we demonstrate that the anti-emetic/anti-psychotic prochlorperazine can be …
Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression
G Escobar, D Moi, A Ranghetti… - Science translational …, 2014 - science.org
The immunosuppressive tumor microenvironment represents a major hurdle to cancer
therapy. We developed a gene transfer strategy into hematopoietic stem cells (HSCs) to …
therapy. We developed a gene transfer strategy into hematopoietic stem cells (HSCs) to …
Engineering a humanized bone organ model in mice to study bone metastases
LC Martine, BM Holzapfel, JA McGovern, F Wagner… - Nature protocols, 2017 - nature.com
Current in vivo models for investigating human primary bone tumors and cancer metastasis
to the bone rely on the injection of human cancer cells into the mouse skeleton. This …
to the bone rely on the injection of human cancer cells into the mouse skeleton. This …