Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome
A Guemez-Gamboa, LN Nguyen, H Yang, MS Zaki… - Nature …, 2015 - nature.com
Docosahexanoic acid (DHA) is the most abundant omega-3 fatty acid in brain, and, although
it is considered essential, deficiency has not been linked to disease,. Despite the large mass …
it is considered essential, deficiency has not been linked to disease,. Despite the large mass …
Structural basis of omega-3 fatty acid transport across the blood–brain barrier
Docosahexaenoic acid is an omega-3 fatty acid that is essential for neurological
development and function, and it is supplied to the brain and eyes predominantly from …
development and function, and it is supplied to the brain and eyes predominantly from …
A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome
V Alakbarzade, A Hameed, DQY Quek, BA Chioza… - Nature …, 2015 - nature.com
The major pathway by which the brain obtains essential omega-3 fatty acids from the
circulation is through a sodium-dependent lysophosphatidylcholine (LPC) transporter …
circulation is through a sodium-dependent lysophosphatidylcholine (LPC) transporter …
[HTML][HTML] Structural Insights into the Transport Mechanism of the Human Sodium-dependent Lysophosphatidylcholine Transporter MFSD2A*♦
Major facilitator superfamily domain containing 2A (MFSD2A) was recently characterized as
a sodium-dependent lysophosphatidylcholine transporter expressed at the blood-brain …
a sodium-dependent lysophosphatidylcholine transporter expressed at the blood-brain …
Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination
T Harel, DQY Quek, BH Wong, A Cazenave-Gassiot… - Neurogenetics, 2018 - Springer
The major facilitator superfamily domain-containing protein 2A (MFSD2A) is a constituent of
the blood-brain barrier and functions to transport lysophosphatidylcholines (LPCs) into the …
the blood-brain barrier and functions to transport lysophosphatidylcholines (LPCs) into the …
[HTML][HTML] Novel serum and urinary metabolites associated with diabetic retinopathy in three Asian cohorts
DQY Quek, F He, R Sultana, R Banu, ML Chee… - Metabolites, 2021 - mdpi.com
Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus, a metabolic
disorder, but understanding of its pathophysiology remains incomplete. Meta-analysis of …
disorder, but understanding of its pathophysiology remains incomplete. Meta-analysis of …
The longitudinal association between cognitive impairment and incident visual impairment in a multiethnic Asian population: a prospective cohort study
TA Vu, P Gupta, FZY Leow, EK Fenwick… - Age and …, 2022 - academic.oup.com
Background The relationship between baseline cognitive impairment (CI) and incident
visual impairment (VI) in Asians is unclear. Objective To determine the associations between …
visual impairment (VI) in Asians is unclear. Objective To determine the associations between …
Relationship between vision impairment and employment
YX Chai, ATL Gan, EK Fenwick, AY Sui… - British Journal of …, 2023 - bjo.bmj.com
Aims To examine the relationship between vision impairment (VI) and employment
outcomes in a multiethnic Asian population. Methods We included 7608 Asian individuals …
outcomes in a multiethnic Asian population. Methods We included 7608 Asian individuals …
Visual field defects and myopic macular degeneration in Singapore adults with high myopia
Aims To characterise the association between visual field (VF) defects and myopic macular
degeneration (MMD) in highly myopic adults without glaucoma. Methods Participants (n …
degeneration (MMD) in highly myopic adults without glaucoma. Methods Participants (n …
[HTML][HTML] Cardiovascular disease and thinning of retinal nerve fiber layer in a multi-ethnic Asian population: the Singapore epidemiology of eye diseases study
S Majithia, DQY Quek, ML Chee, ZW Lim… - Frontiers in …, 2023 - frontiersin.org
Introduction Our study aimed to examine the relationship between cardiovascular diseases
(CVD) with peripapillary retinal fiber layer (RNFL) and macular ganglion cell-inner plexiform …
(CVD) with peripapillary retinal fiber layer (RNFL) and macular ganglion cell-inner plexiform …