Genetic and epigenetic changes affecting cells and molecules involved in Behçet's disease
offer new pathways for research, including cytoskeletal protein function, that will provide new …

OBJECTIVE: To study the prognostic value of antibodies to cyclic citrullinated peptide (anti-
CCP) and rheumatoid factor (RF), alone and in combination, in patients with very early …

Objective. The aim of this study was to describe the outcomes and predictors for
development of damage in a large inception cohort of SLE patients. Methods. This was a …

Objective Rheumatoid arthritis (RA) is associated with increased cardiovascular event (CVE)
risk. The impact of statins in RA is not established. We assessed whether atorvastatin is …

Objective. To determine whether low-dose ciclosporin was a more effective corticosteroid-
sparing agent than AZA in patients with SLE. Methods. Patients with SLE requiring a change …

Abstract Objectives The epidemiology of Behçet's disease (BD) has not been well
characterized in the UK. Evidence on the risk of cardiovascular disease, thromboembolic …

SIR, Calcinosis is a debilitating manifestation of many connective tissue diseases,
particularly JDM and SSc. Little is known about the pathogenesis of this condition, and its …

Background This study reports on the analysis of the application and diagnostic
predictability of the revised 2014 ICBD criteria in an unselected cohort of UK patients, and …

Chronic progressive multisystem granulomatous disease is seen in 10–30% of patients with
sarcoidosis and can result in end organ damage. Corticosteroids are the mainstay of …

Aims Severe ocular inflammation is a blinding ophthalmological emergency. This study
evaluates the efficacy and patient tolerance of a validated regime of pulsed intravenous …