User profiles for "author:Earl Silverman"

Earl Silverman

University of Toronto
Verified email at sickkids.ca
Cited by 29697

Transplacental fetal treatment improves the outcome of prenatally diagnosed complete atrioventricular block without structural heart disease

ET Jaeggi, JC Fouron, ED Silverman, G Ryan… - Circulation, 2004 - Am Heart Assoc
Background—Untreated isolated fetal complete atrioventricular block (CAVB) has a
significant mortality rate. A standardized treatment approach, including maternal …

Prevalence and burden of pediatric-onset systemic lupus erythematosus

S Kamphuis, ED Silverman - Nature Reviews Rheumatology, 2010 - nature.com
Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease with a
highly variable clinical course. Pediatric-onset SLE (pSLE) represents 10–20% of all SLE …

The role of antimalarial agents in the treatment of SLE and lupus nephritis

SJ Lee, E Silverman, JM Bargman - Nature Reviews Nephrology, 2011 - nature.com
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that affects
various organs. Lupus nephritis is one of the most common, and most important, serious …

[HTML][HTML] Etanercept in children with polyarticular juvenile rheumatoid arthritis

DJ Lovell, EH Giannini, A Reiff… - … England Journal of …, 2000 - Mass Medical Soc
Background We evaluated the safety and efficacy of etanercept, a soluble tumor necrosis
factor receptor (p75): Fc fusion protein, in children with polyarticular juvenile rheumatoid …

Difference in disease features between childhood‐onset and adult‐onset systemic lupus erythematosus

HI Brunner, DD Gladman, D Ibañez… - … : Official Journal of …, 2008 - Wiley Online Library
Objective To investigate potential differences between childhood‐onset and adult‐onset
systemic lupus erythematosus (SLE). Methods An inception cohort with childhood‐onset …

A randomized, placebo‐controlled trial of infliximab plus methotrexate for the treatment of polyarticular‐course juvenile rheumatoid arthritis

N Ruperto, DJ Lovell, R Cuttica… - … : Official Journal of …, 2007 - Wiley Online Library
Objective To evaluate the safety and efficacy of infliximab in the treatment of juvenile
rheumatoid arthritis (JRA). Methods This was an international, multicenter, randomized …

[HTML][HTML] Improved diagnostic yield compared with targeted gene sequencing panels suggests a role for whole-genome sequencing as a first-tier genetic test

AC Lionel, G Costain, N Monfared, S Walker… - Genetics in …, 2018 - nature.com
Purpose Genetic testing is an integral diagnostic component of pediatric medicine. Standard
of care is often a time-consuming stepwise approach involving chromosomal microarray …

Clinical and laboratory characteristics and long-term outcome of pediatric systemic lupus erythematosus: a longitudinal study

LT Hiraki, SM Benseler, PN Tyrrell, D Hebert… - The Journal of …, 2008 - Elsevier
OBJECTIVES: To determine the frequency and characteristics of clinical signs, symptoms,
laboratory findings, and medication use in children with pediatric systemic lupus …

Outcome of children with fetal, neonatal or childhood diagnosis of isolated congenital atrioventricular block: a single institution's experience of 30 years

ET Jaeggi, RM Hamilton, ED Silverman… - Journal of the American …, 2002 - jacc.org
Objectives: We reviewed our institution's experience with isolated (congenital) third-degree
atrioventricular block (CAVB) to identify pre-and post-natal predictors of mortality and the …

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

JC Taylor, HC Martin, S Lise, J Broxholme, JB Cazier… - Nature …, 2015 - nature.com
To assess factors influencing the success of whole-genome sequencing for mainstream
clinical diagnosis, we sequenced 217 individuals from 156 independent cases or families …