PURPOSE: To investigate the mechanism by which traumatic macular hole closes
spontaneously. DESIGN: Consecutive observational case series of three patients with …

Retinal vasculogenesis and ischemic retinopathies provide good model systems for study of
vascular development and neovascularization (NV), respectively. Vascular endothelial cell …

Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are
mammalian-specific cellular deaminases and have a robust ability to restrain lentivirus …

The most common cause of new blindness in young patients is retinal neovascularization,
and in the elderly is choroidal neovascularization. Therefore, there has been a great deal of …

Flavonoids are one of the major plant pigments for flower colour. Not only coloured
anthocyanins, but also co-pigment flavones or flavonols, accumulate in flowers. To study the …

The major flavonoids accumulated in leaves of Japanese gentian (Gentiana triflora) were
determined as isoorientin (luteolin 6-C-glucoside) and isoorientin 4′-glucoside. A cDNA …

Prothrombin fragment 1+ 2 (F1+ 2) is considered to be useful for diagnosis of thrombosis.
However, the evidence for a diagnosis of thrombosis by F1+ 2 is still not well established …

Nitric oxide (NO) has been shown to have proangiogenic or antiangiogenic effects
depending upon the setting. In this study, we used mice with targeted deletion of one of the …

Expression of platelet-derived growth factor (PDGF)-A and PDGF-B is increased in patients
with proliferative retinopathies in which traction retinal detachments occur. Previous studies …

Mice or humans with photoreceptor degenerations experience permeability and dropout of
retinal capillaries. Loss of photoreceptors results in decreased oxygen usage and thinning of …