Insulinomas associated with multiple endocrine neoplasia type I: the need for a different surgical approach

MJ Demeure, DC Klonoff, JH Karam, QY Duh, OH Clark - Surgery, 1991 - surgjournal.com
Abstract Insulinomas are usually solitary (> 90%) benign pancreatic tumors readily cured by
enucleation or resection. To determine whether the 4% of insulinomas associated with …

Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect

JE Gerich, M Langlois, C Noacco, JH Karam… - Science, 1973 - science.org
Despite excessive glucagon responses to infusion of arginine, plasma glucagon did not rise
in six juvenile-type diabetics during severe insulin-induced hypoglycemia, whereas …

A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes melliitus

GI Bell, S Horita, JH Karam - Diabetes, 1984 - Am Diabetes Assoc
A polymorphic region flanking the human insulin gene on the short arm of chromosome 11,
the insulin-gene-linked DNA polymorphism, can be described as a locus with at least three …

Polymorphic DNA region adjacent to the 5'end of the human insulin gene.

GI Bell, JH Karam, WJ Rutter - Proceedings of the National …, 1981 - National Acad Sciences
The length of a segment of DNA associated with the human insulin gene, which has been
localized to the short arm of chromosome 11, is heterozygous in 63% of 52 individuals …

Prevention of human diabetic ketoacidosis by somatostatin: evidence for an essential role of glucagon

JE Gerich, M Lorenzi, DM Bier… - … England Journal of …, 1975 - Mass Medical Soc
To evaluate the role of glucagon in the pathogenesis of diabetic ketoacidosis in man, we
studied the effect of suppression of glucagon secretion by somatostatin on changes in …

Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone …

JE Gerich, M Lorenzi, DM Bier… - The Journal of …, 1976 - Am Soc Clin Investig
To study the individual effects of glucagon and growth hormone on human carbohydrate and
lipid metabolism, endogenous secretion of both hormones was simultaneously suppressed …

Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin‐dependent diabetes mellitus

NC Sambol, J Chiang, M O'Conner… - The Journal of …, 1996 - Wiley Online Library
This study was conducted to assess the effect of noninsulin‐dependent diabetes mellitus
(NIDDM) and gender on the pharmacokinetics of metformin and to investigate whether or not …

Effects of somatostatin on plasma glucose and glucagon levels in human diabetes mellitus: pathophysiologic and therapeutic implications

JE Gerich, M Lorenzi, V Schneider… - … England Journal of …, 1974 - Mass Medical Soc
To evaluate the role of pancreatic alpha-cell dysfunction in human diabetes mellitus,
somatostatin, an inhibitor of glucagon secretion, was infused (1 mg over two hours) in 10 …

Insulinoma--experience from 1950 to 1995.

MP Boukhman, JH Karam, J Shaver… - Western Journal of …, 1998 - ncbi.nlm.nih.gov
Insulinomas are rare tumors that originate from the islet cells of the pancreas. The purpose
of this study was to analyze our experience in patients with insulinoma and present our …

Characterization of the glucagon response to hypoglycemia in man

JE Gerich, V Schneider, SE Dippe… - The Journal of …, 1974 - academic.oup.com
The present investigation was undertaken to characterize glucagon responses to
hypoglycemia in man. Using a highly specific antiserum, plasma immunoreactive glucagon …