User profiles for "author:Jonathan Kirk"

Jonathan A. Kirk

Associate Professor & Vice Chair, Loyola University Chicago
Verified email at luc.edu
Cited by 2499

Guidelines for in vivo mouse models of myocardial infarction

ML Lindsey, KR Brunt, JA Kirk… - American Journal …, 2021 - journals.physiology.org
Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

Electromechanical dyssynchrony and resynchronization of the failing heart

JA Kirk, DA Kass - Circulation research, 2013 - Am Heart Assoc
Patients with heart failure and decreased function frequently develop discoordinate
contraction because of electric activation delay. Often termed dyssynchrony, this further …

The role of heat shock proteins and co-chaperones in heart failure

MJ Ranek, MJ Stachowski… - … Transactions of the …, 2018 - royalsocietypublishing.org
The ongoing contractile and metabolic demands of the heart require a tight control over
protein quality control, including the maintenance of protein folding, turnover and synthesis …

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

DI Lee, G Zhu, T Sasaki, GS Cho, N Hamdani… - Nature, 2015 - nature.com
Cyclic guanosine monophosphate (cGMP) is a second messenger molecule that transduces
nitric-oxide-and natriuretic-peptide-coupled signalling, stimulating phosphorylation changes …

Reinforcing rigor and reproducibility expectations for use of sex and gender in cardiovascular research

ML Lindsey, AJ LeBlanc… - American Journal …, 2021 - journals.physiology.org
In 1993, the National Institutes of Health (NIH) enacted the Revitalization Act to establish
guidelines for inclusion of women and minorities in clinical research. In 2016, the NIH …

Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart

P Zhang, JA Kirk, W Ji, CG Dos Remedios, DA Kass… - Circulation, 2012 - Am Heart Assoc
Background—Human cardiac troponin I is known to be phosphorylated at multiple amino
acid residues by several kinases. Advances in mass spectrometry allow sensitive detection …

[HTML][HTML] Creatine kinase–mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved

A Gupta, A Akki, Y Wang, MK Leppo… - The Journal of …, 2012 - Am Soc Clin Investig
ATP is required for normal cardiac contractile function, and it has long been hypothesized
that reduced energy delivery contributes to the contractile dysfunction of heart failure (HF) …

Right ventricular myofilament functional differences in humans with systemic sclerosis–associated versus idiopathic pulmonary arterial hypertension

S Hsu, KM Kokkonen-Simon, JA Kirk, TM Kolb… - Circulation, 2018 - Am Heart Assoc
Background: Patients with systemic sclerosis (SSc)–associated pulmonary arterial
hypertension (PAH) have a far worse prognosis than those with idiopathic PAH (IPAH). In …

Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction

A Ngkelo, A Richart, JA Kirk, P Bonnin, J Vilar… - Journal of Experimental …, 2016 - rupress.org
Acute myocardial infarction (MI) is a severe ischemic disease responsible for heart failure
and sudden death. Inflammatory cells orchestrate postischemic cardiac remodeling after MI …

[HTML][HTML] Therapeutic targeting of BAG3: considering its complexity in cancer and heart disease

JA Kirk, JY Cheung, AM Feldman - The Journal of Clinical …, 2021 - Am Soc Clin Investig
Bcl2-associated athanogene-3 (BAG3) is expressed ubiquitously in humans, but its levels
are highest in the heart, the skeletal muscle, and the central nervous system; it is also …