User profiles for "author:Jonathan Kirk"
Jonathan A. KirkAssociate Professor & Vice Chair, Loyola University Chicago Verified email at luc.edu Cited by 2499 |
Guidelines for in vivo mouse models of myocardial infarction
Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …
Electromechanical dyssynchrony and resynchronization of the failing heart
Patients with heart failure and decreased function frequently develop discoordinate
contraction because of electric activation delay. Often termed dyssynchrony, this further …
contraction because of electric activation delay. Often termed dyssynchrony, this further …
The role of heat shock proteins and co-chaperones in heart failure
MJ Ranek, MJ Stachowski… - … Transactions of the …, 2018 - royalsocietypublishing.org
The ongoing contractile and metabolic demands of the heart require a tight control over
protein quality control, including the maintenance of protein folding, turnover and synthesis …
protein quality control, including the maintenance of protein folding, turnover and synthesis …
Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease
Cyclic guanosine monophosphate (cGMP) is a second messenger molecule that transduces
nitric-oxide-and natriuretic-peptide-coupled signalling, stimulating phosphorylation changes …
nitric-oxide-and natriuretic-peptide-coupled signalling, stimulating phosphorylation changes …
Reinforcing rigor and reproducibility expectations for use of sex and gender in cardiovascular research
ML Lindsey, AJ LeBlanc… - American Journal …, 2021 - journals.physiology.org
In 1993, the National Institutes of Health (NIH) enacted the Revitalization Act to establish
guidelines for inclusion of women and minorities in clinical research. In 2016, the NIH …
guidelines for inclusion of women and minorities in clinical research. In 2016, the NIH …
Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart
Background—Human cardiac troponin I is known to be phosphorylated at multiple amino
acid residues by several kinases. Advances in mass spectrometry allow sensitive detection …
acid residues by several kinases. Advances in mass spectrometry allow sensitive detection …
[HTML][HTML] Creatine kinase–mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved
A Gupta, A Akki, Y Wang, MK Leppo… - The Journal of …, 2012 - Am Soc Clin Investig
ATP is required for normal cardiac contractile function, and it has long been hypothesized
that reduced energy delivery contributes to the contractile dysfunction of heart failure (HF) …
that reduced energy delivery contributes to the contractile dysfunction of heart failure (HF) …
Right ventricular myofilament functional differences in humans with systemic sclerosis–associated versus idiopathic pulmonary arterial hypertension
Background: Patients with systemic sclerosis (SSc)–associated pulmonary arterial
hypertension (PAH) have a far worse prognosis than those with idiopathic PAH (IPAH). In …
hypertension (PAH) have a far worse prognosis than those with idiopathic PAH (IPAH). In …
Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction
Acute myocardial infarction (MI) is a severe ischemic disease responsible for heart failure
and sudden death. Inflammatory cells orchestrate postischemic cardiac remodeling after MI …
and sudden death. Inflammatory cells orchestrate postischemic cardiac remodeling after MI …
[HTML][HTML] Therapeutic targeting of BAG3: considering its complexity in cancer and heart disease
Bcl2-associated athanogene-3 (BAG3) is expressed ubiquitously in humans, but its levels
are highest in the heart, the skeletal muscle, and the central nervous system; it is also …
are highest in the heart, the skeletal muscle, and the central nervous system; it is also …