In the adult organism, all tissue renewal and regeneration depends ultimately on somatic
stem cells, and the eye is no exception. The importance of limbal stem cells in the …

AIMS To investigate changes in the mechanical compliance of ex vivo human lamina
cribrosa with age. METHODS A laser scanning confocal microscope was used to image the …

AIMS--The age-related changes in the biochemical composition of the collagenous matrix of
the human lamina cribrosa were investigated. METHODS--An age range (3 weeks to 92 …

AIMS/BACKGROUND--The morphological changes in Bruch's membrane and its constituent
collagen seen during aging have been studied extensively but the chemical nature of the …

purpose. Inhibition of TGF-β reduces myofibroblast differentiation and fibrosis in the cornea.
Determining the actions of distinct TGF-β isoforms and their inhibitors during early corneal …

Purpose.: Previous work has suggested a major role of scleral biomechanics in the
pathogenesis of glaucoma. Since fiber orientation in connective tissues is a key determinant …

AIMS To investigate age related alterations in the non-collagenous components of the
human lamina cribrosa. METHODS Fibronectin, elastin, and glial fibrillary acidic protein …

Purpose.: Previous studies have suggested that the lamina cribrosa (LC) and its surrounding
sclera are biomechanically important in the pathogenesis of glaucoma, but many were …

Purpose: Scleral stiffening has been proposed as a treatment for glaucoma to protect the
lamina cribrosa (LC) from excessive intraocular pressure–induced deformation. Here we …

Purpose: Cerebrospinal fluid pressure (CSFp) changes are involved or implicated in various
ocular conditions including glaucoma, idiopathic intracranial hypertension, and visual …