The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

Effective drug therapy to optimally influence disease requires an understanding of a drug's
pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. In …

Children differ from adults in their response to drugs. While this may be the result of changes
in dose exposure (pharmacokinetics [PK]) and/or exposure response (pharmacodynamics …

Objective To assess the value of antenatally determined observed to expected fetal lung
area to head circumference ratio (LHR) in the prediction of postnatal survival in isolated …

BACKGROUND: The methylation status of the human glucocorticoid receptor gene NR3C1
in newborns has been reported to be sensitive to prenatal maternal mood. This study …

Congenital diaphragmatic hernia (CDH) is associated with high mortality and morbidity. To
date, there are no standardized protocols for the treatment of infants with this anomaly …

Objective. To determine mortality and morbidity at discharge from the hospital of a large
population-based cohort of infants who were born at≤ 26 weeks' gestation. Methods …

Objectives To investigate the value of the observed to expected fetal lung area to head
circumference ratio (o/e LHR) and liver position in the prediction of neonatal morbidity in …

Purpose The aim of this in vitro study was to evaluate potential determinants of drug loss in
different ECMO circuits. Methods Midazolam, morphine, fentanyl, paracetamol, cefazolin …

The COVID-19 pandemic may be of particular concern for pregnant and breastfeeding
women. We aimed to explore their beliefs about the coronavirus and COVID-19 vaccine …