Background The reduction of maternal deaths is a key international development goal.
Evidence-based health policies and programmes aiming to reduce maternal deaths need …

Background There is increasing recognition that the use of certain medications contributes
to falls in seniors. Our objective was to update a previously completed meta-analysis looking …

Systematic reviews and meta-analyses are a key element of evidence-based healthcare, yet
they remain in some ways mysterious. Why did the authors select certain studies and reject …

Amyloid-β peptide (Aβ) seems to have a central role in the neuropathology of Alzheimer's
disease (AD). Familial forms of the disease have been linked to mutations in the amyloid …

One hallmark of Alzheimer disease is the accumulation of amyloid β-peptide in the brain and
its deposition as plaques. Mice transgenic for an amyloid β precursor protein (APP) mini …

The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B. 1.1. 529),
first identified in Botswana and South Africa, may compromise vaccine effectiveness and …

Abstract ALZHEIMER'S disease (AD) is the most common cause of progressive intellectual
failure in aged humans. AD brains contain numerous amyloid plaques surrounded by …

In 1985 when a group of experts convened by the World Health Organization in Fortaleza,
Brazil, met to discuss the appropriate technology for birth, they echoed what at that moment …

BACKGROUND The cyclooxygenase (COX) enzyme catalyzes the formation of
prostaglandins, which can affect cell proliferation and alter the response of the immune …

Patient-derived organoids (PDOs) have recently emerged as robust preclinical models;
however, their potential to predict clinical outcomes in patients has remained unclear. We …