About 56% of the drugs currently in use are chiral compounds, and 88% of these chiral
synthetic drugs are used therapeutically as racemates. Only a few of these drugs qualify for …

Background St John's Wort (hypericum perforatum) is an herbal medicine that is frequently
used for therapy of mild depression. Recently, St John's Wort was reported to substantially …

Background In autosomal dominant polycystic kidney disease (ADPKD), aberrant activation
of the mammalian target of rapamycin (mTOR) pathway is associated with progressive …

On a global scale, there is an increasing tendency for a more aggressive treatment of
hypercholesterolemia. Minor effects of statins on brain cholesterol metabolism have been …

The blood-brain barrier possesses active transporters carrying brain-permeable xenobiotics
back into the blood against concentration gradients. We demonstrate that multidrug …

Abstract Background and Objective Lysergic acid diethylamide (LSD) is used recreationally
and in clinical research. The aim of the present study was to characterize the …

Background: The pharmacokinetics of oral lysergic acid diethylamide are unknown despite
its common recreational use and renewed interest in its use in psychiatric research and …

Bile acids (BAs) regulate glucose and lipid metabolism. In longitudinal and case-control-
studies, we investigated the diurnal variation of serum concentrations of the 15 major BAs as …

Determination of quantitative changes in the pattern of serum bile acids is important for the
monitoring of diseases affecting bile acid metabolism. A sensitive and specific high …

The World Health Organization (WHO) declared the COVID-19 outbreak a “Public Health
Emergency of International Concern” on 30 January 2020, after rapid spread from a few …